Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer-Reference-Cited by-同舟云学术

Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

Published:2022-03-15 Issue:14 Volume:9 Page:2104452
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Gupta Prachi¹,Kadamberi Ishaque Pulikkal¹,Mittal Sonam¹,Tsaih Shirng‐Wern¹,George Jasmine¹,Kumar Sudhir¹,Vijayan Dileep K.²³,Geethadevi Anjali¹,Parashar Deepak¹,Topchyan Paytsar⁴,McAlarnen Lindsey¹,Volkman Brian F⁵,Cui Weiguo⁴,Zhang Kam Y. J.³,Di Vizio Dolores⁶,Chaluvally‐Raghavan Pradeep¹⁷⁸,Pradeep Sunila¹⁷⁸^ORCID

Affiliation:

1. Department of Obstetrics and Gynecology Medical College of Wisconsin Milwaukee Wisconsin 53226 USA

2. Laboratory for computational and structural biology Jubilee Center for Medical Research Thrissur Kerala 680006 India

3. Laboratory for Structural Bioinformatics Center for Biosystems Dynamics Research Riken 230‐0045 Japan

4. Department of Microbiology and Immunology MCW and Versiti Blood Research Institute Milwaukee Wisconsin 53226 USA

5. Department of Biochemistry Medical College of Wisconsin Milwaukee 53226 USA

6. Department of Surgery Pathology and Laboratory Medicine Samuel Oschin Comprehensive Cancer Institute Cedars‐Sinai Medical Center Los Angeles CA 90048 USA

7. Department of Physiology Medical College of Wisconsin Milwaukee Wisconsin 53226 USA

8. Medical College of Wisconsin Cancer Center Medical College of Wisconsin Milwaukee Wisconsin 53226 USA

Funder

Ovarian Cancer Research Fund Alliance

U.S. Department of Defense

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202104452

Reference34 articles.

1. Association of PD-L1 expression by immunohistochemistry and gene microarray with molecular subtypes of ovarian tumors

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3. Roles of sphingosine-1-phosphate signaling in cancer

4. S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

5. Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis

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