A Temporal PROTAC Cocktail‐Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells

Author:

Liu Fang1,Wang Xuan1,Duan Jianli1,Hou Zhijie2,Wu Zhouming1,Liu Lingling3,Lei Hanqi4,Huang Dan5,Ren Yifei5,Wang Yue2,Li Xinyan1,Zhuo Junxiao1,Zhang Zijian1,He Bin1,Yan Min1,Yuan Huiming6,Zhang Lihua6,Yan Jinsong5,Wen Shijun1,Wang Zifeng1ORCID,Liu Quentin123

Affiliation:

1. Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China

2. Institute of Cancer Stem Cell Dalian Medical University Dalian 116044 China

3. Department of Hematology the Third Affiliated Hospital of Sun Yat‐sen University Guangzhou 510630 China

4. Department of Urology Kidney and Urology Center Pelvic Floor Disorders Center The Seventh Affiliated Hospital Sun Yat‐sen University Shenzhen 518000 China

5. Department of Hematology the Second Affiliated Hospital of Dalian Medical University Dalian 116027 China

6. CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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