A Temporal PROTAC Cocktail‐Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells-Reference-Cited by-同舟云学术

A Temporal PROTAC Cocktail‐Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells

Published:2022-06-02 Issue:22 Volume:9 Page:2104823
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Liu Fang¹,Wang Xuan¹,Duan Jianli¹,Hou Zhijie²,Wu Zhouming¹,Liu Lingling³,Lei Hanqi⁴,Huang Dan⁵,Ren Yifei⁵,Wang Yue²,Li Xinyan¹,Zhuo Junxiao¹,Zhang Zijian¹,He Bin¹,Yan Min¹,Yuan Huiming⁶,Zhang Lihua⁶,Yan Jinsong⁵,Wen Shijun¹,Wang Zifeng¹^ORCID,Liu Quentin¹²³

Affiliation:

1. Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China

2. Institute of Cancer Stem Cell Dalian Medical University Dalian 116044 China

3. Department of Hematology the Third Affiliated Hospital of Sun Yat‐sen University Guangzhou 510630 China

4. Department of Urology Kidney and Urology Center Pelvic Floor Disorders Center The Seventh Affiliated Hospital Sun Yat‐sen University Shenzhen 518000 China

5. Department of Hematology the Second Affiliated Hospital of Dalian Medical University Dalian 116027 China

6. CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202104823

Reference66 articles.

1. Aurora-A — A guardian of poles

2. Aurora A, mitotic entry, and spindle bipolarity

3. Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia

4. Aurora- A/STK15 T + 91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types

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