Photothermal Fibrous Chitosan/Polydopamine Sponge for Intraoperative Hemostasis and Prevention of Tumor Recurrence in Hepatocellular Carcinoma Resection

Author:

Mu Lanxin1,Qi Luhe2,Long Haitao1,Huang Jing2,Zhong Zibiao1,Shi Xiaowen2,Chen Chaoji2ORCID,Ye Qifa1ORCID

Affiliation:

1. National Quality Control Center for Donated Organ Procurement Hubei Key Laboratory of Medical Technology on Transplantation Hubei Clinical Research Center for Natural Polymer Biological Liver Hubei Engineering Center of Natural Polymer‐based Medical Materials, Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University Wuhan 430071 China

2. School of Resource and Environmental Science Hubei International Scientific and Technological Cooperation Base of Sustainable Resource and Energy Hubei Engineering Center of Natural Polymers‐Based Medical Materials Hubei Biomass‐Resource Chemistry and Environmental Biotechnology Key Laboratory Wuhan University Wuhan 430079 China

Abstract

AbstractHepatectomy, a surgical procedure for liver cancer, is often plagued by high recurrence rates worldwide. The recurrence of liver cancer is primarily attributed to microlesions in the liver, changes in the immune microenvironment, and circulating tumor cells in the bloodstream. To address this issue, a novel intervention method that combines intraoperative hemostasis with mild photothermal therapy is proposed, which has the potential to ablate microlesions and improve the immune microenvironment simultaneously. Specifically, the integrated strategy is realized based on the fibrous chitosan/polydopamine sponge (CPDS), which is constructed from shearing‐flow‐induced oriented hybrid chitosan fibers and subsequent self‐assembly of polydopamine. The CPDS demonstrates high elasticity, excellent water absorption, and photothermal conversion performance. The results confirm the efficient hemostatic properties of the fibrous CPDS in various bleeding models. Notably, in subcutaneous and orthotopic postoperative recurrence and metastasis models of hepatocellular carcinoma, the fibrous CPDS significantly inhibits local tumor recurrence and distant metastasis. Moreover, the combination with lenvatinib can substantially enhance the antitumor effect. This comprehensive treatment strategy offers new insights into hepatectomy of liver cancer, representing a promising approach for clinical management.

Funder

National Natural Science Foundation of China

Hebei Provincial Key Research Projects

Zhongnan Hospital of Wuhan University

Wuhan University

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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