Self‐Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy

Author:

Gao Shan12,Miura Yutaka12ORCID,Sumiyoshi Akira3,Ohno Satoshi12,Ogata Keisuke12,Nomoto Takahiro124,Matsui Makoto1,Honda Yuto12,Suzuki Minoru5,Iiyama Megumi3,Osada Kensuke3,Aoki Ichio3,Nishiyama Nobuhiro126ORCID

Affiliation:

1. Laboratory for Chemistry and Life Science Tokyo Institute of Technology R1‐11, 4259 Nagatsuta‐cho, Midori‐ku Yokohama Kanagawa 226‐8503 Japan

2. Department of Life Science and Technology School of Life Science and Technology Tokyo Institute of Technology 4259 Nagatsuta‐cho, Midori‐ku Yokohama Kanagawa 226‐8503 Japan

3. Institute for Quantum Medical Science National Institutes for Quantum Science and Technology Anagawa 4‐9‐1, Inage Chiba 263‐8555 Japan

4. Department of Life Sciences Graduate School of Arts and Sciences The University of Tokyo 3‐8‐1 Komaba, Meguro‐ku Tokyo 153‐8902 Japan

5. Division of Particle Radiation Oncology Particle Radiation Oncology Research Center Institute for Integrated Radiation and Nuclear Science Kyoto University 2–1010, Asashiro‐nishi, Kumatori‐cho, Sennan‐gun Osaka 590‐0494 Japan

6. Innovation Center of Nanomedicine (iCONM) Kawasaki Institute of Industrial Promotion 3‐25‐14 Tonomachi Kawasaki Kanagawa 210‐0821 Japan

Abstract

AbstractNano‐sized contrast agents (NCAs) hold potential for highly specific tumor contrast enhancement during magnetic resonance imaging. Given the quantity of contrast agents loaded into a single nano‐carrier and the anticipated relaxation effects, the current molecular design approaches its limits. In this study, a novel molecular mechanism to augment the relaxation of NCAs is introduced and demonstrated. NCA formation is driven by the intramolecular self‐folding of a single polymer chain that possesses systematically arranged hydrophilic and hydrophobic segments in water. Utilizing this self‐folding molecular design, the relaxivity value can be elevated with minimal loading of gadolinium complexes, enabling sharp tumor imaging. Furthermore, the study reveals that this NCA can selectively accumulate into tumor tissues, offering effective anti‐tumor results through gadolinium neutron capture therapy. The efficacy and versatility of this self‐folding molecular design underscore its promise for cancer diagnosis and treatment.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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