Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy-Reference-Cited by-同舟云学术

Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple‐Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy

Published:2021-09-13 Issue:21 Volume:8 Page:2100974
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Adv. Sci.

Author:

Lei Josh Haipeng¹²³^ORCID,Lee Mi‐Hye⁴,Miao Kai¹²³,Huang Zebin¹,Yao Zhicheng⁵,Zhang Aiping¹²,Xu Jun¹²,Zhao Ming¹²,Huang Zenan⁶,Zhang Xin¹²,Chen Si¹²,Jiaying NG¹,Feng Yuzhao¹,Xing Fuqiang¹²,Chen Ping¹²,Sun Heng¹²³,Chen Qiang¹²³,Xiang Tingxiu⁷,Chen Lin⁸,Xu Xiaoling¹²³,Deng Chu‐Xia¹²³^ORCID

Affiliation:

1. Cancer Center Faculty of Health Sciences University of Macau Macau Macau SAR 999078 China

2. Institute of Translational Medicine Faculty of Health Sciences University of Macau Macau Macau SAR 999078 China

3. MOE Frontier Science Centre for Precision Oncology University of Macau Taipa Macau Macau SAR 999078 China

4. Department of Oncology Georgetown‐Lombardi Comprehensive Cancer Center Georgetown University Washington DC 20057 USA

5. Department of General Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong 510000 China

6. Department of Thyroid and Breast Surgery The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong 510000 China

7. Oncology Laboratory The First Affiliated hospital of Chongqing Medical University Chongqing 400016 China

8. Center of Bone Metabolism and Repair Department of Rehabilitation Medicine State Key Laboratory of Trauma Burns and Combined Injury Trauma Center Research Institute of Surgery Daping Hospital Third Military Medical University Chongqing 400038 China

Funder

Universidade de Macau

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202100974

Reference51 articles.

1. Global cancer statistics

2. Genome-wide association study identifies novel breast cancer susceptibility loci

3. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

4. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer

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