Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis-Reference-Cited by-同舟云学术

Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis

Published:2022-01-12 Issue:7 Volume:9 Page:2103228
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Mao Jianhua¹^ORCID,Zhu Kongkai²,Long Zhangbiao¹,Zhang Huimin²³,Xiao Bing¹,Xi Wenda⁴,Wang Yun¹,Huang Jiansong¹,Liu Jingqiu²,Shi Xiaofeng¹,Jiang Hao²,Lu Tian²,Wen Yi²,Zhang Naixia²,Meng Qian²,Zhou Hu²,Ruan Zheng¹,Wang Jin¹,Luo Cheng²³⁵,Xi Xiaodong¹

Affiliation:

1. State Key Laboratory of Medical Genomics Shanghai Institute of Hematology Collaborative Innovation Center of Hematology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

2. Drug Discovery and Design Center the Center for Chemical Biology State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai 201203 China

3. School of Life Science and Technology Shanghai Tech University Shanghai 201210 China

4. Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

5. School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced Study UCAS Hangzhou 310024 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202103228

Reference63 articles.

1. Therapeutic approaches in arterial thrombosis

2. Discovery of novel antagonists of glycoprotein IIb/IIIa-mediated platelet aggregation through virtual screening

3. Current and future antiplatelet therapies: emphasis on preserving haemostasis

4. Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

5. Targeting Integrin and Integrin Signaling in Treating Thrombosis

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