CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4‐Fatty Acid <i>β</i> ‐Oxidation Pathway-Reference-Cited by-同舟云学术

CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4‐Fatty Acid β ‐Oxidation Pathway

Published:2022-05-23 Issue:21 Volume:9 Page:2105126
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Li Hongquan¹,Song Junjiao¹,He Yifei¹,Liu Yizhe¹,Liu Zhen¹,Sun Weili²,Hu Weiguo¹²,Lei Qun‐Ying¹,Hu Xin²,Chen Zhiao¹,He Xianghuo¹²³^ORCID

Affiliation:

1. Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China

2. Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer Center Fudan University Shanghai 200032 China

3. Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing 211166 China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202105126

Reference65 articles.

1. The Emerging Hallmarks of Cancer Metabolism

2. Cancer Cell Metabolism: One Hallmark, Many Faces

3. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

4. Cancer Cell Metabolism: Warburg and Beyond

5. The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

Cited by 33 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Liquidambaric acid inhibits the proliferation of hepatocellular carcinoma cells by targeting PPARα-RXRα to down-regulate fatty acid metabolism;Toxicology and Applied Pharmacology;2024-09

2. Role of ACSL4 in modulating farnesoid X receptor expression and M2 macrophage polarization in HBV‐induced hepatocellular carcinoma;MedComm;2024-09

3. The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast;Epigenetics & Chromatin;2024-08-27

4. The relationship and clinical significance of lactylation modification in digestive system tumors;Cancer Cell International;2024-07-15

5. Loss of OVOL2 in Triple‐Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics;Advanced Science;2024-04-16