Affiliation:
1. Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong 518055 P. R. China
2. Key Laboratory of Theoretical Organic Chemistry and Function Molecule of Ministry of Education School of Chemistry and Chemical Engineering Hunan University of Science and Technology Xiangtan 411201 P. R. China
3. School of Pharmacy Shenzhen University Medical School Shenzhen University Shenzhen Guangdong 518055 P. R. China
Abstract
AbstractHere, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β‐carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization of β‐carbolines with high yields and enantioselectivity (up to 83% yield and 95% ee). This enantioselective multicomponent Minisci protocol exhibits step economy, high chemo‐/enantio‐selective control, and good functional group tolerance, allowing access to a variety of valuable chiral β‐carbolines. Notably, diazo compounds are suitable radical precursors in enantioselective cascade radical reactions. Moreover, the efficiency and practicality of this approach are demonstrated by the asymmetric synthesis of bioactive compounds and natural products.
Funder
National Natural Science Foundation of China
Cited by
1 articles.
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