THQ–Xanthene: An Emerging Strategy to Create Next‐Generation NIR‐I/II Fluorophores

Author:

Mao Zhiqiang12,Rha Hyeonji2,Kim Jungryun2,You Xinru3,Zhang Fan1,Tao Wei3ORCID,Kim Jong Seung2

Affiliation:

1. College of Health Science and Engineering College of Chemistry and Chemical Engineering Hubei University Wuhan 430062 China

2. Department of Chemistry Korea University Seoul 02841 South Korea

3. Center for Nanomedicine and Department of Anesthesiology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA

Abstract

AbstractNear‐infrared fluorescence imaging is vital for exploring the biological world. The short emissions (<650 nm) and small Stokes shifts (<30 nm) of current xanthene dyes obstruct their biological applications since a long time. Recently, a potent and universal THQ structural modification technique that shifts emission to the NIR‐I/II range and enables a substantial Stokes shift (>100 nm) for THQ‐modified xanthene dyes is established. Thus, a timely discussion of THQ–xanthene and its applications is extensive. Hence, the advent, working principles, development trajectory, and biological applications of THQ–xanthene dyes, especially in the fields of fluorescence probe‐based sensing and imaging, cancer theranostics, and super‐resolution imaging, are introduced. It is envisioned that the THQ modification tactic is a simple yet exceptional approach to upgrade the performance of conventional xanthene dyes. THQ–xanthene will advance the strides of xanthene‐based potentials in early fluorescent diagnosis of diseases, cancer theranostics, and imaging‐guided surgery.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hubei Province

National Research Foundation of Korea

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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