Spatial Transcriptomics: Technical Aspects of Recent Developments and Their Applications in Neuroscience and Cancer Research-Reference-Cited by-同舟云学术

Spatial Transcriptomics: Technical Aspects of Recent Developments and Their Applications in Neuroscience and Cancer Research

Published:2023-04-07 Issue:16 Volume:10 Page:
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Park Han‐Eol¹²³^ORCID,Jo Song Hyun⁴,Lee Rosalind H.⁵^ORCID,Macks Christian P.¹²^ORCID,Ku Taeyun⁴^ORCID,Park Jihwan⁵^ORCID,Lee Chung Whan⁶^ORCID,Hur Junho K.⁷^ORCID,Sohn Chang Ho¹²^ORCID

Affiliation:

1. Center for Nanomedicine Institute for Basic Science Yonsei University Seoul 03722 Republic of Korea

2. Graduate Program in Nanobiomedical Engineering Advanced Science Institute Yonsei University Seoul 03722 Republic of Korea

3. School of Biological Sciences Seoul National University Seoul 08826 Republic of Korea

4. Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

5. School of Life Sciences Gwangju Institute of Science and Technology (GIST) Gwangju 61005 Republic of Korea

6. Department of Chemistry Gachon University Seongnam Gyeonggi‐do 13120 Republic of Korea

7. Department of Genetics College of Medicine Hanyang University Seoul 04763 Republic of Korea

Abstract

AbstractSpatial transcriptomics is a newly emerging field that enables high‐throughput investigation of the spatial localization of transcripts and related analyses in various applications for biological systems. By transitioning from conventional biological studies to “in situ” biology, spatial transcriptomics can provide transcriptome‐scale spatial information. Currently, the ability to simultaneously characterize gene expression profiles of cells and relevant cellular environment is a paradigm shift for biological studies. In this review, recent progress in spatial transcriptomics and its applications in neuroscience and cancer studies are highlighted. Technical aspects of existing technologies and future directions of new developments (as of March 2023), computational analysis of spatial transcriptome data, application notes in neuroscience and cancer studies, and discussions regarding future directions of spatial multi‐omics and their expanding roles in biomedical applications are emphasized.

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202206939

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