Affiliation:
1. Department of Gastroenterology Xinqiao Hospital Army Medical University NO.183, Xinqiao Street Chongqing 400037 China
2. Department of Chemical and Biochemical Engineering and School of Biomedical Engineering The University of Western Ontario London Ontario N6A 5B9 Canada
3. Chongqing Municipality Clinical Research Center for Gastroenterology Chongqing 400037 China
4. Department of Mechanical Engineering University of Manitoba Winnipeg Manitoba R3T 2N2 Canada
Abstract
AbstractNature presents the most beautiful patterns through evolving. Here, a layered porous pattern in golden ratio (0.618) is reported from a type of mushroom ‐Dictyophora Rubrovalvata stipe (DRS). The hierarchical structure shows a mathematical correlation with the golden ratio. This unique structure leads to superior mechanical properties. The gradient porous structure from outside to innermost endows it with asymmetrical hydrophilicity. A mathematical model is then developed to predict and apply to 3D printed structures. The mushroom is then explored to repair gastric perforation because the stomach is a continuous peristaltic organ, and the perforated site is subject to repeated mechanical movements and pressure changes. At present, endoscopic clipping is ineffective in treating ulcerative perforation with fragile surrounding tissues. Although endoscopic implant occlusion provides a new direction for the treatment of gastric ulcers, but the metal or plastic occluder needs to be removed, requiring a second intervention. Decellularized DRS (DDRS) is found with asymmetric water absorption rate, super‐compressive elasticity, shape memory, and biocompatibility, making it a suitable occluder for the gastric perforation. The efficacy in blocking gastric perforation and promoting healing is confirmed by endoscopic observation and tissue analysis during a 2‐month study.
Funder
National Natural Science Foundation of China
Cited by
1 articles.
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