Affiliation:
1. Department of Ultrasonography Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University 570311 Haikou P. R. China
2. Materdicine Lab, School of Life Sciences Shanghai University Shanghai 200444 P. R. China
3. Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Institute of Ultrasound in Medicine 200032 Shanghai P. R. China
Abstract
AbstractSonodynamic therapy (SDT) is a non‐invasive therapeutic modality with high tissue‐penetration depth to induce reactive oxygen species (ROS) generation for tumor treatment. However, the clinical translation of SDT is restricted seriously by the lack of high‐performance sonosensitizers. Herein, the distinct single atom iron (Fe)‐doped graphitic‐phase carbon nitride (C3N4) semiconductor nanosheets (Fe‐C3N4 NSs) are designed and engineered as chemoreactive sonosensitizers to effectively separate the electrons (e−) and holes (h+) pairs, achieving high yields of ROS generation against melanoma upon ultrasound (US) activation. Especially, the single atom Fe doping not only substantially elevates the separation efficiency of the e−‐h+ pairs involved in SDT, but also can serve as high‐performance peroxidase mimetic enzyme to catalyze the Fenton reaction for generating abundant hydroxyl radicals, therefore synergistically augmenting the curative effect mediated by SDT. As verified by density functional theory simulation, the doping of Fe atom significantly promotes the charge redistribution in the C3N4‐based NSs, which improves their synergistic SDT/chemodynamic activities. Both the in vitro and in vivo assays demonstrate that Fe‐C3N4 NSs feature an outstanding antitumor effect by aggrandizing the sono‐chemodynamic effect. This work illustrates a unique single‐atom doping strategy for ameliorating the sonosensitizers, and also effectively expands the innovative anticancer‐therapeutic applications of semiconductor‐based inorganic sonosensitizers.
Funder
National Natural Science Foundation of China
Shanghai Shuguang Program
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
30 articles.
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