Optimizing performance of semi-continuous cell culture in an ambr15™ microbioreactor using dynamic flux balance modeling-Reference-Cited by-同舟云学术

Optimizing performance of semi-continuous cell culture in an ambr15™ microbioreactor using dynamic flux balance modeling

Published:2017-11-30 Issue:2 Volume:34 Page:420-431
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Kelly William¹^ORCID,Veigne Sorelle²,Li Xianhua¹,Subramanian Shyam Sundar³,Huang Zuyi¹,Schaefer Eugene²

Affiliation:

1. Villanova University, Chemical Engineering; Villanova PA 19085

2. Janssen R&D, cAPI Large Molecule Pharmaceutical, Development and Manufacturing Sciences; Malvern PA

3. Teva Pharmaceuticals, Biologics CMC; North Wales PA

Publisher

Wiley

Subject

Biotechnology

Reference21 articles.

1. A brief history of perfusion biomanufacturing: how high-concentration cultures will characterize the factory of the future;Bonham-Carter;BioProcess Int,2011

2. Understanding and modeling alternating tangential flow filtration for perfusion cell culture;Kelly;Biotechnol Progr,2014

3. Fletcher T. 2014

4. Novel automated micro-scale bioreactor technology: a qualitative and quantitative mimic for early process development;Lewis;Bioprocess J,2010

5. Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors;Hsu;Cytotechnology,2012

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Establishment of a semi-continuous scale-down clone screening model for intensified perfusion culture;Biotechnology Letters;2024-07-27

2. Small-scale perfusion mimic cultures in the ambr250 HT bioreactor system;Biochemical Engineering Journal;2024-07

3. A nutrition algorithm to optimize feed and medium composition using genome-scale metabolic models;Metabolic Engineering;2023-03

4. Non-invasive real-time monitoring of cell concentration and viability using Doppler ultrasound;SLAS Technology;2022-12

5. Shake tube perfusion cell cultures are suitable tools for the prediction of limiting substrate, CSPR , bleeding strategy, growth and productivity behavior;Journal of Chemical Technology & Biotechnology;2021-07-28