Affiliation:
1. Department of Clinical Laboratory Qilu Hospital of Shandong University Jinan China
2. Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan China
Abstract
AbstractCisplatin is the first‐line chemotherapy for gastric cancer (GC). However, its efficacy is dampened by the development of chemoresistance, which leads to poor prognosis in GC patients. Recently, evidence has revealed that circular RNAs (circRNAs) and dysregulation of autophagy‐dependent ferroptosis play critical roles in cancer chemoresistance. Herein, for the first time we report that circHIPK3 has a vital role in GC cisplatin resistance. CircHIPK3 regulated cisplatin resistance by targeting autophagy and ferroptosis. In brief, knockdown circHIPK3 decreased GC cell cisplatin resistance by enhancing ferroptosis via the miR‐508‐3p/Bcl‐2/beclin1/SLC7A11 axis. Taken together, our results demonstrate that ferroptosis is a promising strategy to ameliorate cisplatin resistance. Importantly, serum exosomal circHIPK3 could also be a noninvasive indicator to evaluate cisplatin resistance in GC.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Subject
Cell Biology,Clinical Biochemistry,Physiology
Cited by
1 articles.
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