Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced in CHO cells
Author:
Affiliation:
1. School of Biosciences, Industrial Biotechnology Centre University of Kent Canterbury, Kent UK
2. Biologics Division Lonza Biologcs Slough UK
3. National Institute for Bioprocessing Research and Training Blackrock Co. Dublin Ireland
Funder
Biotechnology and Biological Sciences Research Council
Publisher
Wiley
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.28230
Reference46 articles.
1. Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an Fc fusion protein
2. Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production
3. A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells
4. Studies to Prevent Degradation of Recombinant Fc-Fusion Protein Expressed in Mammalian Cell Line and Protein Characterization
5. Charting the dynamics of translation
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3. Application of Formulation Principles to Stability Issues Encountered During Processing, Manufacturing, and Storage of Drug Substance and Drug Product Protein Therapeutics;Journal of Pharmaceutical Sciences;2023-11
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