Nonclinical vaccine safety evaluation: advantages of continuous temperature monitoring using abdominally implanted data loggers

Author:

Kaaijk Patricia1,van der Ark Arno A. J.1,van Amerongen Geert2,van den Dobbelsteen Germie P. J. M.1

Affiliation:

1. Unit Vaccinology; Centre for Infectious Disease Control, National Institute for Public Health and the Environment; Bilthoven; the Netherlands

2. Joint Centre for Laboratory Animal Studies; Netherlands Vaccine Institute; Bilthoven; the Netherlands

Publisher

Wiley

Subject

Toxicology

Reference18 articles.

1. Endotoxin tolerance: new mechanisms, molecules and clinical significance;Biswas;Trends Immunol.,2009

2. Non-clinical safety evaluation of novel vaccines and adjuvants: new products, new strategies;Brennan;Vaccine,2005

3. Comparison of rectal, microchip transponder, and infrared thermometry techniques for obtaining body temperature in the laboratory rabbit (Oryctolagus cuniculus);Chen;J. Am. Assoc. Lab. Anim. Sci.,2006

4. Bacterial endotoxins;Galanos;Infection,1986

5. Clinical implications of endotoxin concentrations in vaccines;Geier;Ann. Pharmacother.,2002

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