Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study

Author:

Rambau Peter F12,Vierkant Robert A3,Intermaggio Maria P4,Kelemen Linda E5,Goodman Marc T6,Herpel Esther7,Pharoah Paul D89,Kommoss Stefan10,Jimenez‐Linan Mercedes11,Karlan Beth Y12,Gentry‐Maharaj Aleksandra13,Menon Usha13,Polo Susanna Hernando14,Candido dos Reis Francisco J15,Doherty Jennifer Anne16,Gayther Simon A171819,Sharma Raghwa2021,Larson Melissa C3,Harnett Paul R2223,Hatfield Emma1,de Andrade Jurandyr M15,Nelson Gregg S24,Steed Helen25,Schildkraut Joellen M26,Carney Micheal E27,Høgdall Estrid2829,Whittemore Alice S3031,Widschwendter Martin13,Kennedy Catherine J2232,Wang Frances3334,Wang Qin9,Wang Chen35,Armasu Sebastian M3,Daley Frances3637,Coulson Penny38,Jones Micheal E38,Anglesio Micheal S39,Chow Christine40,de Fazio Anna2232,García‐Closas Montserrat3841,Brucker Sara Y42,Cybulski Cezary43,Harris Holly R4445,Hartkopf Andreas D10,Huzarski Tomasz43,Jensen Allan28,Lubiński Jan43,Oszurek Oleg46,Benitez Javier4748,Mina Fady1,Staebler Annette49,Taran Florin Andrei10,Pasternak Jana10,Talhouk Aline50,Rossing Mary Anne4451,Hendley Joy52,Edwards Robert P5354,Fereday Sian52,Modugno Francesmary5455,Ness Roberta B56,Sieh Weiva57,El‐Bahrawy Mona A58,Winham Stacey J3,Lester Jenny12,Kjaer Susanne K2859,Gronwald Jacek43,Sinn Peter60,Fasching Peter A6162,Chang‐Claude Jenny6364,Moysich Kirsten B65,Bowtell David D5266,Hernandez Brenda Y67,Luk Hugh67,Behrens Sabine63,Shah Mitul8,Jung Audrey63,Ghatage Prafull24,Alsop Jennifer8,Alsop Kathryn52,García‐Donas Jesús68,Thompson Pamela J6,Swerdlow Anthony J6970,Karpinskyj Chloe13,Cazorla‐Jiménez Alicia71,García María J4748,Deen Susha72,Wilkens Lynne R67,Palacios José73,Berchuck Andrew74,Koziak Jennifer M75,Brenton James D76,Cook Linda S7778,Goode Ellen L79,Huntsman David G395080,Ramus Susan J481,Köbel Martin1ORCID,

Affiliation:

1. Department of Pathology and Laboratory Medicine University of Calgary, Foothills Medical Center Calgary AB Canada

2. Pathology Department Catholic University of Health and Allied Sciences‐Bugando Mwanza Tanzania

3. Department of Health Sciences Research, Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA

4. School of Women's and Children's Health Faculty of Medicine, University of NSW Sydney Sydney NSW Australia

5. Department of Public Health Sciences Medical University of South Carolina Charleston SC USA

6. Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars‐Sinai Medical Center Los Angeles CA USA

7. National Center for Tumor Diseases, University of Heidelberg Heidelberg Germany

8. Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge Cambridge UK

9. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge Cambridge UK

10. Department of Women's Health Tübingen University Hospital Tübingen Germany

11. Department of Histopathology Addenbrookes Hospital Cambridge UK

12. Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars‐Sinai Medical Center Los Angeles CA USA

13. Gynaecological Cancer Research Centre, Women's Cancer, Institute for Women's Health, University College London London UK

14. Medical Oncology Service Hospital Universitario Funcación Alcorcón Alcorcón Spain

15. Department of Gynecology and Obstetrics, Ribeirão Preto Medical School University of São Paulo Ribeirão Preto Brazil

16. Department of Population Health Sciences Huntsman Cancer Institute, University of Utah Salt Lake City UT USA

17. Department of Preventive Medicine, Keck School of Medicine University of Southern California Los Angeles CA USA

18. Center for Cancer Prevention and Translational Genomics Samuel Oschin Comprehensive Cancer Institute, Cedars‐Sinai Medical Center Los Angeles CA USA

19. Department of Biomedical Sciences Cedars‐Sinai Medical Center Los Angeles CA USA

20. Pathology West ICPMR Westmead Westmead Hospital, The University of Sydney Sydney NSW Australia

21. University of Western Sydney at Westmead Hospital Westmead NSW Australia

22. Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney Sydney NSW Australia

23. The Crown Princess Mary Cancer Centre Westmead, Sydney‐West Cancer Network, Westmead Hospital Sydney NSW Australia

24. Department of Oncology, Division of Gynecologic Oncology, Cumming School of Medicine University of Calgary Calgary AB Canada

25. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Royal Alexandra Hospital Edmonton AB Canada

26. Department of Public Health Sciences University of Virginia Charlottesville VA USA

27. John A. Burns School of Medicine, Department of Obstetrics and Gynecology University of Hawaii Honolulu HI USA

28. Department of Virus, Lifestyle and Genes Danish Cancer Society Research Center Copenhagen Denmark

29. Molecular Unit, Department of Pathology Herlev Hospital, University of Copenhagen Copenhagen Denmark

30. Department of Health Research and Policy – Epidemiology Stanford University School of Medicine Stanford CA USA

31. Department of Biomedical Data Science Stanford University School of Medicine Stanford CA USA

32. Department of Gynaecological Oncology Westmead Hospital Sydney NSW Australia

33. Cancer Control and Population Sciences Duke Cancer Institute Durham NC USA

34. Department of Community and Family Medicine Duke University Medical Center Durham NC USA

35. Department of Health Sciences Research Mayo Clinic Rochester MN USA

36. Division of Breast Cancer Research Institute of Cancer Research London UK

37. Division of Bioscience Brunel University London UK

38. Division of Genetics and Epidemiology Institute of Cancer Research London UK

39. Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada

40. Genetic Pathology Evaluation Centre, Vancouver General Hospital and University of British Columbia Vancouver BC Canada

41. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA

42. Department of Gynecology and Obstetrics University of Tübingen Tübingen Germany

43. Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland

44. Program in Epidemiology, Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA USA

45. Department of Environmental Medicine, Division of Nutritional Epidemiology Karolinska Institutet Stockholm Sweden

46. International Hereditary Cancer Center, Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland

47. Human Cancer Genetics Programme Spanish National Cancer Research Centre (CNIO) Madrid Spain

48. Biomedical Network on Rare Diseases (CIBERER) Madrid Spain

49. Institute of Pathology, Tübingen University Hospital Tübingen Germany

50. British Columbia's Ovarian Cancer Research (OVCARE) Program Vancouver General Hospital, BC Cancer Agency and University of British Columbia Vancouver BC Canada

51. Department of Epidemiology University of Washington Seattle WA USA

52. Department of Research, Cancer Genomics and Genetics Peter MacCallum Cancer Center Melbourne VIC Australia

53. Ovarian Cancer Center of Excellence, Womens Cancer Research Program Magee‐Womens Research Institute and University of Pittsburgh Cancer Institute Pittsburgh PA USA

54. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh School of Medicine Pittsburgh PA USA

55. Womens Cancer Research Center, Magee‐Womens Research Institute and Hillman Cancer Center Pittsburgh PA USA

56. University of Texas MD Anderson Cancer Center Houston TX USA

57. Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai New York NY USA

58. Department of Histopathology, Imperial College London Hammersmith Hospital London UK

59. Department of Gynaecology, Rigshospitalet University of Copenhagen Copenhagen Denmark

60. Department of Pathology Institute of Pathology, University Hospital Heidelberg Heidelberg Germany

61. David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology University of California at Los Angeles Los Angeles CA USA

62. Department of Gynecology and Obstetrics Comprehensive Cancer Center ER‐EMN, University Hospital Erlangen, Friedrich‐Alexander‐University Erlangen‐Nuremberg Erlangen Germany

63. Division of Cancer Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany

64. Cancer Epidemiology Group University Cancer Center Hamburg (UCCH), University Medical Center Hamburg‐Eppendorf Hamburg Germany

65. Division of Cancer Prevention and Control Roswell Park Cancer Institute Buffalo NY USA

66. Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville VIC Australia

67. Cancer Epidemiology Program University of Hawaii Cancer Center Honolulu HI USA

68. Medical Oncology Service HM Hospitales – Centro Integral Oncológico HM Clara Campal Madrid Spain

69. Division of Genetics and Epidemiology The Institute of Cancer Research London UK

70. Division of Breast Cancer Research The Institute of Cancer Research London UK

71. Pathology Department Fundación Jiménez Díaz‐Quiron Salud Madrid Spain

72. Department of Histopathology Queen's Medical Centre, Nottingham University Hospitals NHS Trust Nottingham UK

73. Pathology Department, IRYCIS, CIBERONC Universidad de Alcalá, Hospital Universitario Ramón y Cajal Madrid Spain

74. Department of Obstetrics and Gynecology Duke University Medical Center Durham NC USA

75. Alberta Health Services‐Cancer Care Calgary AB Canada

76. Cancer Research UK Cambridge Institute, University of Cambridge Cambridge UK

77. University of New Mexico Health Sciences Center, University of New Mexico Albuquerque NM USA

78. Department of Cancer Epidemiology and Prevention Research Alberta Health Services Calgary AB Canada

79. Department of Health Science Research, Division of Epidemiology Mayo Clinic Rochester MN USA

80. Department of Molecular Oncology BC Cancer Agency Research Centre Vancouver BC Canada

81. The Kinghorn Cancer Centre, Garvan Institute of Medical Research Sydney NSW Australia

Funder

National Cancer Institute

Cancer Institute NSW

Pomorski Uniwersytet Medyczny W Szczecinie

Cancer Research UK

Minnesota Ovarian Cancer Alliance

Mayo Foundation for Medical Education and Research

Kræftens Bekæmpelse

National Center for Advancing Translational Sciences

U.S. Department of Defense

Deutsches Krebsforschungszentrum

Ministerio de Economía y Competitividad

Cancer Research Society

Canadian Institutes of Health Research

Medical Research and Materiel Command

National Institutes of Health

Publisher

Wiley

Subject

Pathology and Forensic Medicine

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