Engineering a Medium‐chain Alcohol Dehydrogenase for Efficient Synthesis of ( <i>S</i> )‐N−Boc‐3−pyrrolidinol by Adjusting the Conformational Dynamics of Loops-Reference-Cited by-同舟云学术

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Engineering a Medium‐chain Alcohol Dehydrogenase for Efficient Synthesis of ( S )‐N−Boc‐3−pyrrolidinol by Adjusting the Conformational Dynamics of Loops

Published:2023-01-05 Issue:5 Volume:15 Page:
ISSN:1867-3880
Container-title:ChemCatChem
language:en
Short-container-title:ChemCatChem

Author:

Ye Wenjie¹,Zhang Yuxin¹,Wang Yilin²,Xie Jingwen¹,Liu Yan¹,Yang Lin¹,Wang Hualei¹^ORCID,Wei Dongzhi¹

Affiliation:

1. State Key Laboratory of Bioreactor Engineering New World Institute of Biotechnology East China University of Science and Technology 130 Meilong Road Shanghai 200237 P. R. China

2. Georgetown Preparatory School North Bethesda MD 20852 USA

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cctc.202201175

Reference51 articles.

1.

2. Development of a practical biocatalytic process for ( S )- N -Boc-3-hydroxypiperidine synthesis

3. Origins of stereoselectivity in evolved ketoreductases

4. Directed Evolution of Carbonyl Reductase from Rhodosporidium toruloides and Its Application in Stereoselective Synthesis of tert-Butyl (3R,5S)-6-Chloro-3,5-dihydroxyhexanoate

5. A pooled analysis of three phase III studies to investigate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist, in the treatment of overactive bladder

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3. Integrated engineering at distal site and active center regulates stereoselectivity and activity of carbonyl reductase towards N-Boc-pyrrolidone;Molecular Catalysis;2024-04

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