Affiliation:
1. CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides & Chemical Biology Ministry of Education International Joint Research Center for Intelligent Biosensing Technology and Health College of Chemistry Central China Normal University (CCNU) 430079 Wuhan Hubei P. R. China
2. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Center for Excellence in Molecular Synthesis University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Road 200032 Shanghai P. R. China
Abstract
AbstractThe asymmetric 1,4‐difunctionalization of 1,3‐enynes represents a concise and highly efficient strategy for the preparation of chiral allenes. Herein, we developed a copper‐catalyzed three‐component asymmetric radical 1,4‐aryl/alkynylation of 1,3‐enynes by employing inexpensive, readily available, and highly reactive diaryliodonium salts as precursors to generate aryl radicals. The success of this reaction relied on the use of iminophenyl oxazolinylphenylamines (IPOPA) as chiral ligands. The reaction exhibited good compatibility with various alkynes, 1,3‐enynes, and diaryliodonium salts, providing an effective method for constructing highly enantioselective tetrasubstituted axially chiral allene compounds.
Funder
National Natural Science Foundation of China
Chinese Academy of Sciences
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis
Cited by
8 articles.
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