Affiliation:
1. School of Chemical Engineering and Technology Hebei University of Technology Tianjin 300130 P. R. China
2. College of Food Science and Biology Hebei University of Science & Technology Shijiazhuang 050018 P. R. China
Abstract
AbstractThe synthesis of enantiopure chiral cyclic amines is of critical importance but highly challenging. In this study, a metal‐enzyme hybrid catalyst was fabricated by the co‐immobilization of palladium nanoparticles and monoamine oxidases on dendritic organosilica nanoparticles (DONs) for chemoenzymatic deracemization, furnishing a panel of chiral cyclic amines in high enantioselectivities (96–98 % ee). Catalyst optimization revealed that the ultra‐high specific surface area, mesoporous channels and hydrophobic microenvironment of the DONs are responsible for the improved catalyst stability, activity and catalytic efficiency.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Natural Science Foundation of Hebei Province
Natural Science Foundation of Tianjin City
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis
Cited by
6 articles.
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