Dendritic Organosilica Nanoparticle‐Based Metal‐Enzyme Hybrid Catalyst for Chemoenzymatic Deracemization of Cyclic Amines

Author:

Dong Lele1,Zhou Liya1,Liu Guanhua1,Gao Jing1,Bai Jing2,Liu Yunting1ORCID,Jiang Yanjun1

Affiliation:

1. School of Chemical Engineering and Technology Hebei University of Technology Tianjin 300130 P. R. China

2. College of Food Science and Biology Hebei University of Science & Technology Shijiazhuang 050018 P. R. China

Abstract

AbstractThe synthesis of enantiopure chiral cyclic amines is of critical importance but highly challenging. In this study, a metal‐enzyme hybrid catalyst was fabricated by the co‐immobilization of palladium nanoparticles and monoamine oxidases on dendritic organosilica nanoparticles (DONs) for chemoenzymatic deracemization, furnishing a panel of chiral cyclic amines in high enantioselectivities (96–98 % ee). Catalyst optimization revealed that the ultra‐high specific surface area, mesoporous channels and hydrophobic microenvironment of the DONs are responsible for the improved catalyst stability, activity and catalytic efficiency.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Hebei Province

Natural Science Foundation of Tianjin City

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis

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