Affiliation:
1. School of Chemistry and Environmental Engineering Yancheng Teachers University Yancheng City Jiangsu Province 224007 People's Republic of China
2. Department of Organic Chemistry College of Chemistry Beijing University of Chemical Technology 15 Beisanhuan East Rd. Beijing 100029 People's Republic of China
Abstract
AbstractThe broad applications of primary alkyl amines in various fields have spurred extensive interests in synthetic organic chemistry. Recently, the reductive amination of carboxylic acids has become an attractive and practical strategy for synthesizing primary alkyl amines, due to their wide availability and bench stability. However, the inherent stability and higher oxidation state of carboxylic acids render this new strategy with new challenges. This Concept provides a summary of the recent advancements in the reductive aminations of carboxylic acids, specifically focusing on the catalytic tactics, underlying mechanisms, and applications in the synthesis of valuable products.
Funder
Natural Science Research of Jiangsu Higher Education Institutions of China
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis