Affiliation:
1. College of Chemistry and Materials Science Sichuan Normal University Chengdu 610066 P. R. of China
2. State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. of China
Abstract
AbstractCarbonyl addition serves as a strategically straightforward and versatile approach for synthesizing alcohols, which are often encountered within bioactive molecules. Herein, we present a ligand‐free, nickel‐catalyzed carbonyl addition process using organoboron reagents. This method enables efficient arylation of readily available ketones or aldehydes, affording a variety of tertiary and secondary alcohols. Key highlights of this protocol include the obviation of external ligands and the tolerance to many functional groups and heterocycles, thereby enhancing its practicality and utility in synthetic organic chemistry.
Funder
Chinese Academy of Sciences
Program of Shanghai Academic Research Leader
Natural Science Foundation of Ningbo Municipality