Affiliation:
1. CEA CNRS NIMBE Université Paris Saclay 91191 Gif-sur-Yvette France
2. CIMEX - École Polytechnique 91128 Palaiseau France
Abstract
AbstractHere we report on the use of formic acid as a green and safe reagent for the N‐methylation of primary amides in the presence of a Pd/In2O3 solid catalyst. No additive is needed and primary amides are selectively N‐methylated in good to excellent yields. The reaction operates through a formylation/reduction pathway, leaving the amide carbonyl untouched.