Affiliation:
1. Institut des Molécules et Matériaux du Mans, IMMM UMR 6283 CNRS - Le Mans Université Avenue Olivier Messiaen 72085 Le Mans Cedex 09 France
Abstract
AbstractThe first studies on [Ru]‐catalyzed Asymmetric Ring‐Closing Ene‐Yne Metathesis (ARCEYM) are disclosed in this communication. The desymmetrization of achiral ene‐diyne substrates afforded the corresponding exo cyclic compounds in good yields and enantioselectivities (up to 69 % ee). The methodology provided a straightforward access to functionalized scaffolds displaying alkyne and diene useful for further functionalization such as [4+2] cycloaddition reaction.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis