Enantioselective Ni‐Catalyzed Three‐Component Dicarbofunctionalization of Alkenes

Author:

Dong Zhan1,Song Liangliang2,Chen Liang‐An1ORCID

Affiliation:

1. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 P. R. China

2. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical Engineering Nanjing Forestry University Nanjing 210037 P. R. China

Abstract

AbstractAsymmetric multicomponent reactions are considered as efficient protocols for constructing complex chiral molecules because of their step‐ and atom‐economy. Nickel‐catalyzed asymmetric three‐component dicarbofunctionalization of alkenes has been well developed in recent years, which is used in the area of total synthesis of natural products and late‐stage modification of drugs because of the rapid incorporation of chiral sp3‐enriched carbon centers. In this concept, the significant breakthroughs of this field are summarized, together with the related mechanisms. Moreover, the remaining challenges and potential opportunities of multicomponent dicarbofunctionalization are also highlighted.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Catalysis

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