Affiliation:
1. State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life Sciences Hubei University Wuhan 430062 China
2. Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 China
Abstract
AbstractThe escalating demand for fossil fuels has raised environmental concerns, urging the exploration of biosynthetic pathways for renewable hydrocarbon fuels. Terminal alkenes (α‐alkenes) emerge as “drop‐in” compatible fuels and chemicals, holding the potential to replace traditional fossil fuels. Fatty acid decarboxylases present a promising route for converting fatty acids into α‐alkenes, underscoring the imperative need for comprehending the catalytic mechanisms governing these enzymes in the quest for renewable biofuel production. The reported fatty acid decarboxylases entail the involvement of heme and non‐heme iron cofactors in the redox process. In this review, we summarize the reaction mechanisms of four iron‐dependent fatty acid decarboxylases (OleTJE, OleTPRN, UndA, and UndB), providing a critical analysis of the factors influencing chemical selectivity and catalytic performance.
Funder
National Natural Science Foundation of China