Should we reduce routine surveillance imaging in pediatric germ cell tumors?-Reference-Cited by-同舟云学术

Should we reduce routine surveillance imaging in pediatric germ cell tumors?

Published:2023-01-10 Issue:3 Volume:70 Page:
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatric Blood & Cancer

Author:

Terenziani Monica¹^ORCID,Barretta Francesco²,Gattuso Giovanna¹^ORCID,Bisogno Gianni³^ORCID,Conte Massimo⁴,Crocoli Alessandro⁵^ORCID,De Pasquale Maria Debora⁶,Biasoni Davide⁷,Spreafico Filippo¹^ORCID,D'Angelo Paolo⁸

Affiliation:

1. Pediatric Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy

2. Medical Statistics, Biometry and Bioinformatics Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy

3. Hematology Oncology Division Department of Women's and Children's Health University of Padova Padua Italy

4. UOC Oncologia IRCCS Istituto Gaslini Genoa Italy

5. General Surgery Department Bambino Gesù Children's Hospital, IRCCS Rome Italy

6. Pediatric Hematology/Oncology Cell and Gene Therapy Department Bambino Gesù Children's Hospital, IRCCS Rome Italy

7. Urologic Surgery Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy

8. Pediatric Hematology and Oncology Unit, ARNAS “Civico Di Cristina and Benfratelli” Hospitals Palermo Italy

Abstract

AbstractThis paper retrospectively investigated the site and the detection method of relapses in children and adolescents with malignant germ cell tumors enrolled in the TCGM‐AIEOP‐2004 Study and subsequently developed a relapse, in order to evaluate a possible reduction in radiological exposure during follow‐up. Including all malignant cases, serum tumor markers identified a relapse in more than 70% and, according to the selection criteria published by Children Oncology Group in 2018, in more than 90% of cases. These results confirm the importance of serum tumor markers as a relapse detection method, with possible reduction of radiology exams in specific subgroups.

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.30200

Reference12 articles.

1. Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration

2. Diagnostic, Prognostic and Predictive Markers in Pediatric Germ Cell Tumors—Past, Present and Future

3. Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group

4. Malignant ovarian germ cell tumors in pediatric patients: The AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) study

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