In Vitro absorption and secretory quotients: Practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates-Reference-Cited by-同舟云学术

In Vitro absorption and secretory quotients: Practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates

Published:2004-10 Issue:10 Volume:93 Page:2567-2572
ISSN:0022-3549
Container-title:Journal of Pharmaceutical Sciences
language:en
Short-container-title:Journal of Pharmaceutical Sciences

Author:

Thiel-Demby Victoria E.,Tippin Timothy K.,Humphreys Joan E.,Serabjit-Singh Cosette J.,Polli Joseph W.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference7 articles.

1. Role of p-glycoprotein in pharmacokinetics;Lin;Clin Pharmacokinet,2003

2. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview;Schinkel;Adv Drug Deliv Rev,2002

3. Rational use of in vitro P-glycoprotein assays in drug discovery;Polli;J Pharmacol Exp Ther,2001

4. Passive permeability and P-glycoprotein mediated efflux differentiate CNS and non-CNS marketed drugs;Mahar Doan;J Pharmacol Exp Ther,2002

5. Efflux ratio cannot assess p-glycoprotein-mediated attenuation of absorptive transport: Asymmetric effect of p-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers;Troutman;Pharm Res,2003

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