1. Department of Cardiology; Castle Hill Hospital, Hull York Medical School (at University of Hull); Kingston upon Hull HU16 5JQ UK
2. University of Göttingen Medical School; Department of Cardiology and Pneumology; Göttingen Germany
3. National Heart & Lung Institute and National Institute of Health Research Cardiovascular Biomedical Research Unit; Royal Brompton & Harefield Hospitals, Imperial College; London UK
4. Robertson Centre for Biostatistics and Clinical Trials; University of Glasgow; Glasgow UK