Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI

Author:

Major Megan1ORCID,Freund Malika K.2,Burch Kathryn S.1,Mancuso Nicholas3,Ng Michael4,Furniss Dominic456,Pasaniuc Bogdan1237,Ophoff Roel A.128ORCID

Affiliation:

1. Bioinformatics Interdepartmental ProgramUniversity of California Los AngelesLos Angeles California

2. Department of Human Genetics, David Geffen School of MedicineUniversity of California Los AngelesLos Angeles California

3. Department of Pathology and Laboratory Medicine, David Geffen School of MedicineUniversity of California Los AngelesLos Angeles California

4. Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal ScienceUniversity of OxfordOxford UK

5. Department of Plastic and Reconstructive SurgeryOxford University Hospitals NHS Foundation Trust, John Radcliffe HospitalOxford UK

6. NIHR Biomedical Research Centre, NDORMSUniversity of OxfordOxford UK

7. Department of Biomathematics, David Geffen School of MedicineUniversity of California Los AngelesLos Angeles CA USA

8. Center for Neurobehavioral GeneticsUniversity of California Los AngelesLos Angeles California

Funder

Foundation for the National Institutes of Health

Wellcome Trust

Institut National Du Cancer

Publisher

Wiley

Subject

Genetics(clinical),Epidemiology

Reference87 articles.

1. A global reference for human genetic variation;1000 Genomes Project Consortium;Nature,2015

2. Cell fixation and preservation for droplet‐based single‐cell transcriptomics;Alles J.;BMC Biology,2017

3. Approximately independent linkage disequilibrium blocks in human populations;Berisa T.;Bioinformatics,2016

4. Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs;Breton G.;The Journal of Experimental Medicine,2016

5. An atlas of genetic correlations across human diseases and traits;Bulik‐Sullivan B.;Nature Genetics,2015

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