Exposure–Response‐Based Product Profile–Driven Clinical Utility Index for Ipatasertib Dose Selection in Prostate Cancer
Author:
Affiliation:
1. Genentech, Inc. South San Francisco California USA
2. Certara Menlo Park California USA
Funder
Genentech
Publisher
Wiley
Subject
Pharmacology (medical),Modeling and Simulation
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12394
Reference22 articles.
1. The Use of Clinical Utility Assessments in Early Clinical Development
2. The Clinical Utility Index as a Practical Multiattribute Approach to Drug Development Decisions
3. Benefit–risk assessment: the use of clinical utility index
4. A quantitative benefit-risk assessment approach to improve decision making in drug development: Application of a multicriteria decision analysis model in the development of combination therapy for overactive bladder
5. Moving Beyond Maximum Tolerated Dose for Targeted Oncology Drugs: Use of Clinical Utility Index to Optimize Venetoclax Dosage in Multiple Myeloma Patients
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4. Drug–Drug Interaction Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Ipatasertib in Combination with Darolutamide in Patients with Advanced Prostate Cancer;Pharmaceutics;2022-10-01
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