A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition-Reference-Cited by-同舟云学术

A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

Published:2019-03-07 Issue:5 Volume:8 Page:273-284
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Emoto Chie¹²,Johnson Trevor N.³,Hahn David¹,Christians Uwe⁴,Alloway Rita R.⁵,Vinks Alexander A.¹²,Fukuda Tsuyoshi¹²

Affiliation:

1. Division of Clinical PharmacologyCincinnati Children's Hospital Medical Center Cincinnati Ohio USA

2. Department of PediatricsUniversity of Cincinnati College of Medicine Cincinnati Ohio USA

3. Simcyp DivisionCertara UK Limited Sheffield UK

4. iC42 Clinical Research and DevelopmentUniversity of Colorado Anschutz Medical Campus Aurora Colorado USA

5. Division of Nephrology and HypertensionDepartment of Internal MedicineUniversity of Cincinnati College of Medicine Cincinnati Ohio USA

Funder

United States National Institutes of Health (NIH)/US Food and Drug Administration

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12392

Reference51 articles.

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3. The disposition of 14C‐labeled tacrolimus after intravenous and oral administration in healthy human subjects;Moller A.;Drug Metab. Dispos.,1999

4. The pharmacokinetics and metabolic disposition of tacrolimus: A comparison across ethnic groups

5. Metabolism of Tacrolimus (FK506) and Recent Topics in Clinical Pharmacokinetics

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