Target‐Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy-Reference-Cited by-同舟云学术

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Target‐Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy

Published:2019-01-08 Issue:3 Volume:8 Page:177-187
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Schropp Johannes¹,Khot Antari²,Shah Dhaval K.²,Koch Gilbert²³

Affiliation:

1. Department of Mathematics and StatisticsUniversity of Konstanz Konstanz Germany

2. Department of Pharmaceutical SciencesSchool of Pharmacy and Pharmaceutical SciencesState University of New York at Buffalo Buffalo New York USA

3. Paediatric Pharmacology and Pharmacometrics ResearchUniversity of Basel Children's Hospital (UKBB) Basel Switzerland

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12369

Reference31 articles.

1. Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

2. Emicizumab Prophylaxis in Hemophilia A with Inhibitors

3. A “Trojan horse” bispecific-antibody strategy for broad protection against ebolaviruses

4. Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia

5. Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies

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1. T-cell redirecting bispecific antibody treatment in multiple myeloma: current knowledge and future strategies for sustained T-cell engagement;Expert Opinion on Biological Therapy;2024-09

2. General quasi-equilibrium multivalent binding model to study diverse and complex drug-receptor interactions of biologics;Journal of Pharmacokinetics and Pharmacodynamics;2024-08-17

3. A Population Pharmacokinetic Model of Tocilizumab in Kidney Transplant Patients Treated for Chronic Active Antibody-Mediated Rejection: Comparison of Plasma Exposure Between Intravenous and Subcutaneous Administration Schemes;BioDrugs;2024-08-15

4. Design of Crosslinking Antibodies For T-Cell Activation: Experimental and Computational Analysis of PD-1/CD137 Bispecific Agents;The AAPS Journal;2024-06-11

5. Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors;PLOS Computational Biology;2024-06-07

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