Pediatric Dosing of Ganciclovir and Valganciclovir: How Model‐Based Simulations Can Prevent Underexposure and Potential Treatment Failure-Reference-Cited by-同舟云学术

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Pediatric Dosing of Ganciclovir and Valganciclovir: How Model‐Based Simulations Can Prevent Underexposure and Potential Treatment Failure

Published:2018-12-18 Issue:3 Volume:8 Page:167-176
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Jorga Karin¹,Reigner Bruno²,Chavanne Clarisse²,Alvaro Giuseppe³,Frey Nicolas²

Affiliation:

1. KarinJorga Life Science Consulting GmbH Basel Switzerland

2. Pharma Research & DevelopmentPharmaceutical Sciences‐Clinical PharmacologyRoche Innovation Center BaselF. Hoffmann‐La Roche Ltd Basel Switzerland

3. Safety Risk Management, Established ProductsF. Hoffmann‐La Roche AG Basel Switzerland

Funder

Roche

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12363

Reference28 articles.

1. Bottom-up Meets Top-down: Complementary Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling for Regulatory Approval of a Dosing Algorithm of Valganciclovir in Very Young Children

2. Pharmacokinetic Profile of Ganciclovir After its Oral Administration and From its Prodrug, Valganciclovir, in Solid Organ Transplant Recipients

3. Valganciclovir Dosing According to Body Surface Area and Renal Function in Pediatric Solid Organ Transplant Recipients

4. Pharmacokinetics of oral valganciclovir solution and intravenous ganciclovir in pediatric renal and liver transplant recipients

5. Pharmacokinetics and Safety of Valganciclovir in Pediatric Heart Transplant Recipients 4 Months of Age and Younger

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1. Assessment of patients’ characteristics associated with the efficacy and safety of oral valganciclovir treatment for infants with symptomatic congenital cytomegalovirus disease;Journal of Infection and Chemotherapy;2024-10

2. Pharmacokinetic and Pharmacodynamic Assessment of Valganciclovir in Infants With Congenital Cytomegalovirus Infection;Therapeutic Drug Monitoring;2024-09-04

3. Questioning the Design of Non‐Inferiority Trials: The Strange Case for Therapeutic Drug Monitoring Absence in Phase III Trials;Clinical Pharmacology & Therapeutics;2024-08-09

4. Optimization of Ganciclovir and Valganciclovir Starting Dose in Children by Machine Learning;Clinical Pharmacokinetics;2024-03-16

5. Body surface area compared to body weight dosing of valganciclovir is associated with increased toxicity in pediatric solid organ transplantation recipients;American Journal of Transplantation;2023-12

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