PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants-Reference-Cited by-同舟云学术

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

Published:2018-06-19 Issue:7 Volume:7 Page:464-473
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Emoto Chie¹²,Johnson Trevor N.³,Neuhoff Sibylle³,Hahn David¹,Vinks Alexander A.¹²,Fukuda Tsuyoshi¹²

Affiliation:

1. Division of Clinical PharmacologyCincinnati Children's Hospital Medical CenterCincinnati Ohio USA

2. Department of Pediatrics, College of MedicineUniversity of CincinnatiCincinnati Ohio USA

3. Certara UK Limited, Simcyp DivisionSheffield S1 2BJ United Kingdom

Funder

Center for Clinical & Translational Science & Training

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12306

Reference48 articles.

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3. Increasing Incidence of the Neonatal Abstinence Syndrome in U.S. Neonatal ICUs

4. Mechanistic Basis of Using Body Size and Maturation to Predict Clearance in Humans

5. Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children

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