Profiling primaquine metabolites in primary human hepatocytes using UHPLC-QTOF-MS with13C stable isotope labeling

Author:

Avula Bharathi1,Tekwani Babu L.,Chaurasiya Narayan D.1,Nanayakkara NP Dhammika1,Wang Yan-Hong1,Khan Shabana I.,Adelli Vijender R.1,Sahu Rajnish1,Elsohly Mahmoud A.,McChesney James D.2,Khan Ikhlas A.,Walker Larry A.

Affiliation:

1. National Center for Natural Products Research, School of Pharmacy; The University of Mississippi; University; MS; 38677; USA

2. Ironstone Separations, Inc; 147 CR 245; Etta; MS; 38627; USA

Publisher

Wiley

Subject

Spectroscopy

Reference49 articles.

1. Primaquine revisited six decades after its discovery;Vale;Eur. J. Med. Chem.,2009

2. 8-Aminoquinolines: future role as antiprotozoal drugs;Tekwani;Curr. Opin. Infect. Dis.,2006

3. Clinical problems associated with the use of primaquine as a tissue schizontocidal and gametocytocidal drug;Clyde;Bull. W.H.O,1981

4. Primaquine sensitivity;Tarlov;Arch Int Med,1962

5. The metabolism of 8-aminoquinoline antimalarial agents;Strother;Bulletin of W. H. O.,1981

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