SinoNasal Microbiota Transfer to treat recalcitrant chronic rhinosinusitis: A case series

Author:

Gill Sandeep K.1,Hernaiz‐Leonardo Juan C.12ORCID,Edens Thaddeus J.3,Pascual Athenea2,Tang Chris1,Fan Judy2,Thamboo Andrew2,Mullings Warren4,Alsaleh Saad5,Alim Bader M.26ORCID,Javer Amin R.2ORCID,Manges Amee R.17

Affiliation:

1. School of Population and Public Health University of British Columbia Vancouver British Columbia Canada

2. St. Paul's Sinus Centre Department of Surgery, University of British Columbia Vancouver British Columbia Canada

3. Devil's Staircase Consulting West Vancouver British Columbia Canada

4. Department of Surgery University Hospital of the West Indies Mona Jamaica

5. Department of Otolaryngology—Head and Neck Surgery King Saud University Riyadh Saudi Arabia

6. Prince Mohammed Bin Abdulaziz Hospital National Guard Health Affairs Medina Saudi Arabia

7. British Columbia Centre for Disease Control Vancouver British Columbia Canada

Abstract

Key points SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days. The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis. These promising SNMT results warrant further study of safety and efficacy.

Funder

Canadian Institutes of Health Research

Publisher

Wiley

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