Maintenance treatment with rucaparib for recurrent ovarian carcinoma in ARIEL3, a randomized phase 3 trial: The effects of best response to last platinum‐based regimen and disease at baseline on efficacy and safety

Author:

Oaknin Ana1,Oza Amit M.2,Lorusso Domenica3,Aghajanian Carol4,Dean Andrew5,Colombo Nicoletta6,Weberpals Johanne I.7ORCID,Clamp Andrew R.8,Scambia Giovanni9ORCID,Leary Alexandra10,Holloway Robert W.11,Amenedo Gancedo Margarita12,Fong Peter C.13,Goh Jeffrey C.14,O’Malley David M.15,Armstrong Deborah K.16,Banerjee Susana17,García‐Donas Jesus18,Swisher Elizabeth M.19,Cameron Terri20,Maloney Lara21,Goble Sandra22,Ledermann Jonathan A.23,Coleman Robert L.24ORCID

Affiliation:

1. Gynaecologic Cancer Programme Vall d’Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d’Hebron, Vall d’Hebron Barcelona Hospital Campus Barcelona Spain

2. Division of Medical Oncology and Hematology Princess Margaret Cancer Centre University Health Network Toronto Canada

3. Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies and Gynecologic Oncology Unit Fondazione IRCCS, Istituto Nazionale dei Tumori Milan Italy

4. Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA

5. Oncology St John of God Subiaco Hospital Subiaco Western Australia Australia

6. Gynecologic Cancer Program University of Milan‐Bicocca and European Institute of Oncology IRCCS Milan Italy

7. Division of Gynecologic Oncology Ottawa Hospital Research Institute Ottawa Canada

8. Department of Medical Oncology The Christie NHS Foundation Trust and University of Manchester Manchester United Kingdom

9. Gynecologic Oncology Unit Fondazione Policlinico Universitario A. Gemelli IRCCS and Scientific Directorate Rome Italy

10. Gynecological Unit, Gustave Roussy Cancer Center INSERM U981, and Groupe d’Investigateurs Nationaux pour l’Etude des Cancers Ovariens Villejuif France

11. Gynecologic Oncology AdventHealth Cancer Institute Orlando Florida USA

12. Medical Oncology Department Oncology Center of Galicia, Doctor Camilo Veiras La Coruña Spain

13. Medical Oncology Department Auckland City Hospital, and University of Auckland Auckland New Zealand

14. Department of Oncology, Cancer Care Services Royal Brisbane and Women’s Hospital, and University of Queensland Herston Queensland Australia

15. Division of Gynecologic Oncology The Ohio State University, James Cancer Center Columbus Ohio USA

16. Oncology, Gynecology and Obstetrics Johns Hopkins Kimmel Cancer Center Baltimore Maryland USA

17. Gynaecology Unit The Royal Marsden NHS Foundation Trust and Institute of Cancer Research London United Kingdom

18. Division of Medical Oncology HM Hospitales—Centro Integral Oncológico Hospital de Madrid Clara Campal Madrid Spain

19. Division of Gynecologic Oncology University of Washington Seattle Washington USA

20. Clinical Science Clovis Oncology UK Ltd Cambridge United Kingdom

21. Clinical Development Clovis Oncology, Inc Boulder Colorado USA

22. Biostatistics Clovis Oncology, Inc Boulder Colorado USA

23. Department of Oncology University College London (UCL) Cancer Institute and UCL Hospitals London United Kingdom

24. Department of Gynecologic Oncology and Reproductive Medicine University of Texas MD Anderson Cancer Center Houston Texas USA

Funder

Memorial Sloan-Kettering Cancer Center

Publisher

Wiley

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology

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