MMP3 single‐nucleotide polymorphisms are associated with noncontact ACL injuries in competing high‐level athletes

Author:

Simunic‐Briski Nina1,Vrgoc Goran23ORCID,Knjaz Damir2,Jankovic Sasa23,Dembic Zlatko4ORCID,Lauc Gordan15

Affiliation:

1. Genos Ltd. Zagreb Croatia

2. Faculty of Kinesiology University of Zagreb Zagreb Croatia

3. Department of Orthopaedic Surgery University Hospital “Sveti Duh” Zagreb Croatia

4. Institute of Oral Biology, Faculty of Dentistry University of Oslo Oslo Norway

5. Faculty of Pharmacy and Biochemistry University of Zagreb Zagreb Croatia

Abstract

AbstractMatrix metalloproteinases (MMPs) play an important role in matrix remodeling, as well as in ligament integrity. Anterior cruciate ligament (ACL) rupture is a severe and frequent knee injury in sports. The aim of this study was to investigate polymorphisms within the MMP3 gene with the predisposition for noncontact ACL rupture in the Croatian professional athletes. One hundred eighty‐seven (95 with ACL rupture occurring through a noncontact mechanism and 92 asymptomatic controls) unrelated Caucasians were recruited between 2016 and 2017. All participants were genotyped for three single‐nucleotide polymorphisms (SNP) within the MMP3 gene: rs591058 C/T, rs650108 A/G, and rs679620 G/A using the pyrosequencing method. For all three investigated SNPs, genotype frequencies have significantly differed between cases and controls. The MMP3 rs591058 TT (p = 0.0012, odds ratio [OR] = 38.541, 95% confidence interval [CI] = 1.7024–8.7254), rs650108 GG (p = 0.0051, OR = 23.338, 95% CI = 1.2899–4.2226) and rs679620 AA (p = 0.0030, OR = 34.750, 95% CI = 1.5266–7.9101) genotypes, as well as haplotype variant T‐G‐A (p = 0.0104, OR = 1.71, 95% CI = 1.13–2.59) were significantly overrepresented in cases compared to controls. These results support association between functional variants within the MMP3 gene and the risk of ACL rupture. Still, further research is needed to corroborate these results in a larger population.

Publisher

Wiley

Subject

Orthopedics and Sports Medicine

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