Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma-Reference-Cited by-同舟云学术

Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma

Published:2014-07-22 Issue:4 Volume:136 Page:965-976
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Int. J. Cancer

Author:

Pencavel Tim D.¹²,Wilkinson Michelle J.¹²,Mansfield David C.¹,Khan Aadil A.¹,Seth Rohit¹,Karapanagiotou Eleni M.¹,Roulstone Victoria¹,Aguilar Richard J.³,Chen Nanhai G.³⁴,Szalay Aladar A.³⁴⁵⁶,Hayes Andrew J.²,Harrington Kevin J.¹

Affiliation:

1. Targeted Therapy Team, The Institute of Cancer Research; London United Kingdom

2. Department of Academic Surgery; Sarcoma/Melanoma Unit, Royal Marsden Hospital NHS Foundation Trust; London United Kingdom

3. Genelux Corporation, San Diego Science Center; San Diego CA

4. Department of Radiation Oncology, Rebecca and John Moores Comprehensive Cancer Center; University of California; San Diego CA

5. Department of Biochemistry, Rudolf Virchow Center for Experimental Biomedicine; University of Würzberg; Am Hubland Germany

6. Institute for Molecular Infection Biology; University of Würzberg; Am Hubland Germany

Funder

Royal College of Surgeons of England

Royal College of Surgeons of Edinburgh

Genelux Corporation

NIHR Biomedical Research Centre at RM/ICR

Sarcoma UK

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference38 articles.

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2. Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience;Eggermont;Ann Surg,1996

3. Isolated limb perfusion for melanoma patients--a review of its indications and the role of tumour necrosis factor-alpha;Grunhagen;Eur J Surg Oncol,2006

4. The palliative value of tumor necrosis factor alpha-based isolated limb perfusion in patients with metastatic sarcoma and melanoma;Grunhagen;Cancer,2006

5. High dose tumor necrosis factor-alpha and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a >90% response rate and limb preservation;Gutman;Cancer,1997

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