Affiliation:
1. Nutrition Sciences Post‐Graduation Program, Department of Nutrition, Center for Biological and Health Sciences Federal University of Sergipe São Cristóvão Sergipe Brazil
2. Nutritional Biochemistry Laboratory, Department of Nutrition, Center for Biological and Health Sciences Federal University of Sergipe São Cristóvão Sergipe Brazil
3. Nutrition in Public Health Post‐Graduation Program, Faculty of Public Health University of São Paulo São Paulo Brazil
4. Department of Nutrition Federal University of Sergipe Lagarto Sergipe Brazil
Abstract
AbstractObjectiveTo evaluate the relationship between vitamin D status and hypertriglyceridemic‐waist (HTW) phenotype and cardiometabolic markers in individuals with type 2 diabetes mellitus (T2DM) living in regions with high solar incidence (10° south).MethodsAn observational, cross‐sectional study, with 122 individuals with T2DM, of both sexes, aged between 19 and 59 years, residing in Sergipe/Brazil. Measurements included serum 25‐hydroxyvitamin D (25[OH]D), glucose, insulin, total cholesterol, LDL‐c, HDL‐c, triacylglycerols, blood pressure, body mass index, %body fat, and waist circumference. Participants were classified by the presence or absence of the HTW phenotype, according to increased waist circumference and triacylglycerols concentrations. Logistic and linear regression models were applied to verify the association among the concentration of 25(OH)D, HTW phenotype, and lipid profile variables.ResultsTriacylglycerols concentrations (p = .013) and %body fat (p = .011) were higher in women with serum 25(OH)D insufficient/deficient than in those with adequate 25(OH)D levels. Individuals with serum 25(OH)D insufficiency/deficiency were 2.595 times more likely to present the HTW phenotype than those with adequate 25(OH)D levels (p = .021). Additionally, a negative association was observed between the concentration of 25(OH)D and total cholesterol (Beta = −0.204, p = .049).ConclusionInsufficiency/deficiency of serum 25(OH)D in individuals with T2DM increases the chances of developing the HTW phenotype.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe
Subject
Genetics,Anthropology,Ecology, Evolution, Behavior and Systematics,Anatomy