Involvement of IL‐17A‐producing TCR γδ T cells in late protective immunity against pulmonary Mycobacterium tuberculosis infection

Author:

Umemura Masayuki12,Okamoto‐Yoshida Yuko1,Yahagi Ayano1,Touyama Seigo12,Nakae Susumu3,Iwakura Yoichiro4,Matsuzaki Goro12

Affiliation:

1. Molecular Microbiology GroupDepartment of Infectious DiseasesTropical Biosphere Research CenterUniversity of the Ryukyus1 SenbaruNishiharaOkinawa903‐0213Japan

2. Department of Host DefenseGraduate School of MedicineUniversity of the Ryukyus1 SenbaruNishiharaOkinawa903‐0213Japan

3. Laboratory of Systems BiologyCenter for Experimental Medicine and Systems BiologyInstitute of Medical ScienceUniversity of Tokyo4‐6‐1 ShiroganedaiMinato‐kuTokyo108‐8639Japan

4. Division of Experimental Animal ImmunologyCenter for Animal Disease ModelsResearch Institute for Biomedical SciencesTokyo University of ScienceChiba278‐0022Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology of Japan

Cooperative Research Grants from the Institute of Tropical Medicine at Nagasaki University (NEKKEN)

Research Program on Emerging and Re-emerging Infectious Diseases from the Japan Agency for Medical Research and development (AMED)

Grant-in-Aids for Scientific Research from Japan Society for Promotion of Science (JSPS)

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference26 articles.

1. WHO.2015. Global tuberculosis report 2015 (World Health Organization Geneva Switzerland).

2. WHO.2010. Multidrug and extensively drug‐resistant TB (M/XDR‐TB): 2010 global report on surveillance and response (World Health Organization Geneva Switzerland).

3. The expanding universe of T-cell subsets: Th1, Th2 and more

4. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

5. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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