Preventing breast milk HIV transmission using broadly neutralizing monoclonal antibodies: One size does not fit all

Author:

Van de Perre Philippe1ORCID,Scarlatti Gabriella2,Moore Penny L.34,Molès Jean‐Pierre1ORCID,Nagot Nicolas1,Tylleskär Thorkild5,Gray Glenda6,Goga Ameena67

Affiliation:

1. Pathogenesis and Control of Chronic and Emerging Infections, INSERM, Etablissement Français du Sang, CHU Montpellier University of Montpellier Montpellier France

2. Viral Evolution and Transmission Unit IRCCS Ospedale San Raffaele Milan Italy

3. MRC Antibody Immunity Research Unit, School of Pathology University of the Witwatersrand Johannesburg South Africa

4. National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS) Johannesburg South Africa

5. Department of Global Public Health and Primary Care, Centre for International Health University of Bergen Bergen Norway

6. South African Medical Research Council Cape Town South Africa

7. Department of Paediatrics and Child Health University of Pretoria Pretoria South Africa

Abstract

Key messages Passive immunoprophylaxis with broadly neutralizing monoclonal antibodies (bNAbs) could be a game changer in the prevention of human immunodeficiency virus (HIV) acquisition. The prevailing view is that available resources should be focused on identifying a fixed combination of at least three bNAbs for universal use in therapeutic and preventive protocols, regardless of target populations or routes of transmission. HIV transmission through breastfeeding is unique: it involves free viral particles and cell‐associated virus from breast milk and, in the case of acute/recent maternal infection, a viral population with restricted Env diversity. HIV transmission through breastfeeding in high incidence/prevalence areas could potentially be eliminated by subcutaneous administration to all newborns of one or two long‐acting bNAbs with extended breadth, high potency, and effector properties (ADCC, phagocytosis) against circulating HIV strains.

Publisher

Wiley

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Challenges towards an AIDS-free generation in Africa and Asia;Current Opinion in HIV and AIDS;2024-07-17

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