Four‐dimensional flow MRI for quantitative assessment of cerebrospinal fluid dynamics: Status and opportunities

Author:

Rivera‐Rivera Leonardo A.12ORCID,Vikner Tomas23,Eisenmenger Laura4,Johnson Sterling C.1,Johnson Kevin M.24

Affiliation:

1. Department of Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA

2. Department of Medical Physics University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA

3. Department of Radiation Sciences, Radiation Physics and Biomedical Engineering Umeå University Umeå Sweden

4. Department of Radiology University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA

Abstract

Neurological disorders can manifest with altered neurofluid dynamics in different compartments of the central nervous system. These include alterations in cerebral blood flow, cerebrospinal fluid (CSF) flow, and tissue biomechanics. Noninvasive quantitative assessment of neurofluid flow and tissue motion is feasible with phase contrast magnetic resonance imaging (PC MRI). While two‐dimensional (2D) PC MRI is routinely utilized in research and clinical settings to assess flow dynamics through a single imaging slice, comprehensive neurofluid dynamic assessment can be limited or impractical. Recently, four‐dimensional (4D) flow MRI (or time‐resolved three‐dimensional PC with three‐directional velocity encoding) has emerged as a powerful extension of 2D PC, allowing for large volumetric coverage of fluid velocities at high spatiotemporal resolution within clinically reasonable scan times. Yet, most 4D flow studies have focused on blood flow imaging. Characterizing CSF flow dynamics with 4D flow (i.e., 4D CSF flow) is of high interest to understand normal brain and spine physiology, but also to study neurological disorders such as dysfunctional brain metabolite waste clearance, where CSF dynamics appear to play an important role. However, 4D CSF flow imaging is challenged by the long T1 time of CSF and slower velocities compared with blood flow, which can result in longer scan times from low flip angles and extended motion‐sensitive gradients, hindering clinical adoption. In this work, we review the state of 4D CSF flow MRI including challenges, novel solutions from current research and ongoing needs, examples of clinical and research applications, and discuss an outlook on the future of 4D CSF flow.

Funder

Alzheimer's Association

National Center for Advancing Translational Sciences

National Institute of Neurological Disorders and Stroke

National Institute on Aging

National Institutes of Health

Publisher

Wiley

Subject

Spectroscopy,Radiology, Nuclear Medicine and imaging,Molecular Medicine

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