Alpha‐1‐acid glycoprotein directly affects the pharmacokinetics and the analgesic effect of methadone in the rat beyond protein binding

Author:

Rodriguez Monica,Ortega Ignacio,Soengas Itziar,Leal Nerea,Suarez Elena,Calvo Rosario,Lukas John C.

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference44 articles.

1. Pharmacokinetics and pharmacodynamics of penbutolol in healthy and cancer subjects: Role of altered protein binding;Aguirre;Res Commun Mol Pathol Pharmacol,1996

2. Serum protein binding of lerisetron, a novel specific 5‐HT3 antagonist, in patients with cancer;Calvo;Cancer Chemother Pharmacol,1998

3. Methadone plasma protein binding: Alterations in cancer and displacement from alpha‐1‐acid glycoprotein;Abramson;Clin Pharmacol Ther,1982

4. Alpha1‐acid glycoprotein (AAG) and serum protein binding of methadone in heroin addicts with abstinence syndrome;Garrido;Int J Clin Pharmacol Ther,1999

5. Interindividual variability of the clinical pharmacokinetics of methadone: Implications for the treatment of opioid dependence;Eap;Clin Pharmacokinet,2002

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