A Model to predict severity of drug-induced liver injury in humans
Author:
Affiliation:
1. Division of Bioinformatics and Biostatistics; National Center for Toxicological Research; US Food and Drug Administration; Jefferson AR
2. Center of Pharmacology and Toxicology; Hannover Medical School; Hannover Germany
Funder
German Federal Ministry for Education and Research as part of the Virtual Liver Network initiative
US Food and Drug Administration's National Center for Toxicological Research
Publisher
Wiley
Subject
Hepatology
Reference37 articles.
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2. Idiosyncratic drug hepatotoxicity;Kaplowitz;Nat Rev Drug Discov,2005
3. Concordance of the toxicity of pharmaceuticals in humans and in animals;Olson;Regul Toxicol Pharmacol,2000
4. Toward predictive models for drug-induced liver injury in humans: are we there yet?;Chen;Biomark Med,2014
5. High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury;Chen;Hepatology,2013
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