Beyond the dose-limiting toxicity period: Dermatologic adverse events of patients on phase 1 trials of the Cancer Therapeutics Evaluation Program

Author:

Drilon Alexander12,Eaton Anne A.1,Schindler Katja3,Gounder Mrinal M.12,Spriggs David R.12,Harris Pamela4,Ivy S. Percy4,Iasonos Alexia1,Lacouture Mario E.1,Hyman David M.12

Affiliation:

1. Department of Medicine; Memorial Sloan Kettering Cancer Center; New York New York

2. Department of Medicine; Weill Cornell Medical College; New York New York

3. Dermatology Department; Medical University of Vienna; Vienna Austria

4. Cancer Therapeutics and Evaluation Program, National Cancer Institute; Bethesda Maryland

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference27 articles.

1. Workshop on phase I study design. Ninth NCI/EORTC New Drug Development Symposium, Amsterdam, March 12, 1996;Arbuck;Ann Oncol,1996

2. An overview of the optimal planning, design, and conduct of phase I studies of new therapeutics;LoRusso;Clin Cancer Res,2010

3. Dose escalation methods in phase I cancer clinical trials;Tourneau;J Natl Cancer Inst,2009

4. Phase I trial design: are new methodologies being put into practice?;Dent;Ann Oncol,1996

5. The effect of hand-foot skin reaction associated with the multikinase inhibitors sorafenib and sunitinib on health-related quality of life;Nardone;J Drugs Dermatol,2012

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