An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding-Reference-Cited by-同舟云学术

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

Published:2015-07-14 Issue:8 Volume:24 Page:1301-1312
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Nyon Mun Peak¹,Prentice Tanya¹,Day Jemma¹,Kirkpatrick John¹,Sivalingam Ganesh N.¹,Levy Geraldine¹,Haq Imran²,Irving James A.²,Lomas David A.²,Christodoulou John¹³,Gooptu Bibek³⁴,Thalassinos Konstantinos¹³

Affiliation:

1. Institute of Structural and Molecular Biology, Division of Biosciences, Division of Biosciences, University College London; London WC1E 6BT United Kingdom

2. Wolfson Institute for Biomedical Research; Division of Medicine, University College London; London WC1E 6BT United Kingdom

3. Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London; London WC1E 7HX United Kingdom

4. Division of Asthma; Allergy and Lung Biology, King's College London, Guy's Hospital; London SE1 9RT United Kingdom

Funder

The Wellcome Trust, The Alpha-1 Foundation

A MRC PhD studentship

The MRC and UCLH NIHR Biomedical Research Centre, GlaxoSmithKline, Wellcome Trust Intermediate Fellowship, The Alpha-1 Foundation

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/pro.2706/fullpdf

Reference61 articles.

1. Conformational changes and disease-serpins, prions and Alzheimer's;Carrell;Curr Opin Struct Biol,1998

2. Alpha-1-antitrypsin deficiency: clinical variability, assessment, and treatment;Stockley;Trends Mol Med,2014

3. The molecular and cellular pathology of α1-antitrypsin deficiency;Gooptu;Trends Mol Med,2014

4. Conformational pathology of the serpins: themes, variations and therapeutic strategies;Gooptu;Annu Rev Biochem,2009

5. Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognised inherited disorder;Sharp;J Lab Clin Med,1969

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