Synthesis of 2‐(pyridylvinyl)chromen‐4‐ones and their <i>N</i>‐oxide analogs for assessment of their biological activities as anticancer agents-Reference-Cited by-同舟云学术

Synthesis of 2‐(pyridylvinyl)chromen‐4‐ones and their N‐oxide analogs for assessment of their biological activities as anticancer agents

Published:2024-01-16 Issue:4 Volume:357 Page:
ISSN:0365-6233
Container-title:Archiv der Pharmazie
language:en
Short-container-title:Archiv der Pharmazie

Author:

Ding Yu Chun¹,Chu Yi‐Cheng²³,Chang Chuan‐Hsin⁴,Liang Jia‐Hua²,Chen Jih‐Jung³⁵,Shih Tzenge‐Lien¹^ORCID

Affiliation:

1. Department of Chemistry Tamkang University New Taipei City Taiwan

2. Institute of Traditional Medicine, School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan

3. Department of Pharmacy, College of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei Taiwan

4. Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology Chang Gung University of Science and Technology Taoyuan Taiwan

5. Department of Medical Research China Medical University Hospital, China Medical University Taichung Taiwan

Abstract

Abstract2‐Styrylchromones have been shown to possess a broad spectrum of biological activities. Replacing the carbon atom in 2‐styrylchromones with a nitrogen atom in the benzene rings forms 2‐(pyridylvinyl)chromen‐4‐ones (aza‐2‐styrylchromones). We have synthesized a series of novel 2‐(pyridylvinyl)chromen‐4‐ones and their pyridine N‐oxides to evaluate them as potential anticancer agents against human non‐small‐cell lung cancer cells (A549). Among the 18 synthesized molecules, compounds 18 and 8a exhibited comparable inhibitory effects to 5‐fluorouracil and showed no toxicity against normal cells.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ardp.202300445

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