Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations-Reference-Cited by-同舟云学术

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Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations

Published:2021-08-19 Issue:11 Volume:354 Page:2100201
ISSN:0365-6233
Container-title:Archiv der Pharmazie
language:en
Short-container-title:Arch Pharm

Author:

Khedr Fathalla¹,Ibrahim Mohamed‐Kamal¹,Eissa Ibrahim H.¹^ORCID,Abulkhair Hamada S.²³^ORCID,El‐Adl Khaled¹⁴^ORCID

Affiliation:

1. Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys) Al‐Azhar University Nasr City Cairo Egypt

2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy Al‐Azhar University Nasr City Cairo Egypt

3. Pharmaceutical Chemistry Department, Faculty of Pharmacy Horus University–Egypt New Damietta Egypt

4. Pharmaceutical Chemistry Department, Faculty of Pharmacy Heliopolis University for Sustainable Development Cairo Egypt

Publisher

Wiley

Subject

Drug Discovery,Pharmaceutical Science

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ardp.202100201

Reference60 articles.

1. Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies

2. In Silico Discovery of Potential VEGFR-2 Inhibitors from Natural Derivatives for Anti-Angiogenesis Therapy

3. Vascular Endothelial Growth Factor Receptors VEGFR-2 and VEGFR-3 Are Localized Primarily to the Vasculature in Human Primary Solid Cancers

4. Overexpression of vascular endothelial growth factor (VEGF) and its cellular receptor KDR (VEGFR-2) in the bone marrow of patients with acute myeloid leukemia

5. Anchor-based classification and type-C inhibitors for tyrosine kinases

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